Welcome to EMINENCE

EMINENCE is a project dedicated to the elimination of onchocerciasis in Africa through a clinical trial assessing the efficacy of moxidectin. Funded by EDCTP, it aims to provide innovative solutions to improve disease control and accelerate progress toward elimination..

EMINENCE: A Commitment to the Elimination of Onchocerciasis in Africa

The EMINENCE project, which stands for Eliminating onchocerciasis with Moxidectin IN ENdemic hotspots of CEntral Africa, aims to combat this neglected disease that affects millions of people. Funded by the EDCTP, the project is based on a clinical trial to test a promising drug, moxidectin. Its objective is to find more effective solutions to stop the transmission of the disease and move towards its elimination. By combining science, innovation, and local engagement, EMINENCE is working towards a future free from onchocerciasis.

Moxidectin Clinical Trial

EMINENCE is conducting a rigorous clinical trial to evaluate the efficacy and safety of moxidectin in the treatment of onchocerciasis, with the goal of optimising disease elimination strategies.

Community-Based Trial

Through a large-scale community study, EMINENCE assesses the real-world effectiveness of moxidectin in reducing onchocerciasis transmission and improving treatment outcomes.

Health Economics

EMINENCE analyses the health burden of onchocerciasis, particularly its morbidity and the potential benefits of its elimination, providing critical data to inform healthcare policies and guide resource allocation.

Mathematical Modelling

EMINENCE employs advanced modelling approaches to project the long-term impact of moxidectin on onchocerciasis control and support evidence-based decision-making.

Social Science

By examining social and behavioural factors, EMINENCE aims to enhance community engagement, improve treatment adherence, and address barriers to disease elimination.

Cost Evaluation

The project includes a comprehensive economic evaluation to determine the financial viability and cost-effectiveness of integrating moxidectin into existing disease control programmes.

Scientific Advisory and Stakeholder Group

Dr. Adrian Hopkins

Prof. Roger Moyou-Somo

Dr. Amy Klion

Dr. Maria Rebollo Polo

Dr. Laura Senyonjo

Prof. Charles Mackenzie

Technical Members of the Consortium

Valérie Verdier

Chairman and CEO of IRD

Prof. Joseph KAMGNO

Founding CEO of ISM

Prof. Mattew Fisher

Professor of Fungal Disease Epidemiology, Imperial College London

Mark Sullivan, AO

MDGH’s founder and managing director

Prof. Francine NTOUMI

CEO of FCRM

About Us

The EMINENCE project is dedicated to eliminating onchocerciasis in Africa through innovative clinical research and the evaluation of moxidectin to enhance disease control and accelerate eradication efforts.